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Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1ß

dc.contributor.authorLiesa, Marc
dc.contributor.authorBorda-d'Água, Bárbara
dc.contributor.authorMedina-Gómez, Gema
dc.contributor.authorLelliott, Christopher J.
dc.contributor.authorPaz, José Carlos
dc.contributor.authorRojo-Álvarez, José Luis
dc.contributor.authorPalacín, Manuel
dc.contributor.authorVidal-Puig, Antonio
dc.contributor.authorZorzano, Antonio
dc.date.accessioned2010-02-22T17:10:53Z
dc.date.available2010-02-22T17:10:53Z
dc.date.issued2008-10-31
dc.identifier.citationLiesa M et al. (2008) Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1b. PLoS One. 2008;3(10):e3613. Epub 2008 Oct 31.es
dc.identifier.otherPMID- 18974884
dc.identifier.urihttp://hdl.handle.net/10115/3352
dc.description.abstractThere is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1beta is associated with a selective reduction in Mitofusin 2 (Mfn2) expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1beta increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1beta-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1beta increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor alpha (ERRalpha). CONCLUSIONS/SIGNIFICANCE: Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1beta in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2.es
dc.description.sponsorshipThis study was supported by research grants from the Ministerio de Educación y Cultura (SAF 2005-00445; SAF2008-03803), Grant 2005SGR00947 from the Generalitat de Catalunya, and CIBERDEM (Instituto de Salud Carlos III). A.Z. is the recipient of a Science Intensification Award from the University of Barcelona. M.L. is the recipient of a predoctoral fellowship from the Ministerio de Educación y Cultura, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es
dc.language.isoenes
dc.publisherPLoS ONEes
dc.subjectBiología y Biomedicinaes
dc.titleMitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1ßes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1371/journal.pone.0003613es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subject.unesco3209.90 Farmacología Experimentales
dc.description.departamentoBioquímica, Fisiología y Genética Molecular


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